Detalhe da pesquisa
1.
The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins.
Invest New Drugs
; 31(3): 535-44, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23054211
2.
Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
FASEB J
; 23(9): 2986-95, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19395476
3.
Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.
Cancer Res
; 67(2): 695-701, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234780
4.
Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents.
Bioorg Med Chem Lett
; 17(24): 6821-4, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17980582
5.
NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
Cancer Res
; 63(17): 5636-45, 2003 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14500406
6.
Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization.
Int J Radiat Oncol Biol Phys
; 89(5): 1106-1114, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25035215
7.
The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.
Clin Cancer Res
; 17(20): 6490-9, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21878537
8.
Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway.
Cancer Res
; 68(2): 364-8, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18199529
9.
Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione.
Chem Res Toxicol
; 20(10): 1528-35, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17854155
10.
Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.
J Biol Chem
; 282(4): 2529-37, 2007 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17127771
11.
The cyclopentenone product of lipid peroxidation, 15-A2t-isoprostane, is efficiently metabolized by HepG2 cells via conjugation with glutathione.
Chem Res Toxicol
; 17(1): 17-25, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14727915